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IACUC: Searching for Alternatives to Painful Procedures Used on Research Animals: Examples

This guides helps you search the literature for alternatives to painful and distressful procedures in animal research

PubMed searches with MeSH and textwords

To refine the procedure by reducing pain

YOUR TOPIC/SPECIES/OBJECTIVE/PROCEDURE

AND

(("Models, Animal"[Mesh] OR "Animal Experimentation"[Mesh])

AND

("Anesthesia and Analgesia"[Mesh] OR "Animal Welfare"[Mesh] OR “Euthanasia, Animal"[Mesh] OR "pain recognition"[tiab] OR "pain assessment"[tiab] OR "pain control"[tiab] OR "pain relief"[tiab] OR anxiolytic*[tiab] OR analges*[tiab] OR anaesth*[tiab] OR anesth*[tiab] OR tranquili*[tiab] OR sedat*[tiab])

 

To identify other animal models

YOUR TOPIC/OBJECTIVE/PROCEDURE **don't include your species in this search**

AND

("Animal Testing Alternatives"[Mesh] OR "Animal Use Alternatives"[Mesh] OR "Animal Welfare"[Mesh] OR (replac*[tiab] AND alternative*[tiab])

 

To identify non-animal models

YOUR TOPIC/OBJECTIVE **don't include your species in this search**

AND

(("Models, Theoretical"[Mesh] OR "Computer Simulation"[Mesh] OR "Cadaver"[Mesh] OR "Culture Techniques"[Mesh] OR "Cells, Cultured"[Mesh] OR "In Vitro Techniques"[Mesh] OR "Tissue Culture Techniques"[Mesh] OR simulat*[tiab])

Web of Science searches with textwords

To refine the procedure by reducing pain

YOUR TOPIC/OBJECTIVE/PROCEDURE

AND

YOUR SPECIES

AND

("animal welfare” OR euthan* OR “pain recognition” OR “pain assessment” OR “pain control” OR “pain relief” OR anxiolytic* OR analges* OR anesth* OR anaesth* OR tranquili* OR sedat*)  

 

To identify other animal models

YOUR TOPIC/OBJECTIVE/PROCEDURE **don't include your species in this search**

AND

(animal* NEAR/3 (alternative OR alternatives)) OR "animal welfare" OR (replac* AND alternative*)

 

To identify non-animal models

 

YOUR TOPIC/OBJECTIVE/PROCEDURE **don't include your species in this search**

AND

(computer NEAR/2 (simulation* OR model*) OR "in silico" OR cadaver* OR "cell culture*" OR "in vitro" OR "tissue culture*" or "culture technique*" or "cultured cell*")