Until 1770, Secretaries were appointed pro tempore. The office of Secretary was created by vote of the Corporation. In 1995, the title of the office was changed to Vice President and Secretary.  The positions of Deputy Secretary, Associate Secretary, and Assistant Secretary were discontinued in 2019.

Warham Williams (1770 - 1776)

Elizur Goodrich (1777 - 1778)

Enoch Huntington (1788 - 1793)

David Ely (1793 - 1816)

Elizur Goodrich (1816 - 1846)

Samuel Rogers Andrew (1846 - 1858)

Wyllys Warner (1858 - 1869)

Franklin B. Dexter (1869 - 1899)

Anson Phelps Stokes (1899 - 1921)

Thomas W. Farnam (1921 - 1923)

Robert M. Hutchins (1923 - 1927)

Carl Albert Lohmann (1927 - 1953)

Reuben A. Holden (1953 - 1971)

Howard S. Weaver (1963 - 1964)

Henry Chauncey, Jr. (1971 - 1980)

William Kessen (1980 - 1981)

John Wilkinson (1981 - 1987)

Sheila W. Wellington (1987 - 1993)

Linda K. Lorimer (1993 - 2012)

Kimberly Goff-Crews (2012 - Present), also Vice President for University Life

Radley H. Daly (1991 - 1997)

Martha C. Highsmith (1999 - 2012)

Martha Schall (2015 - 2019)

Richard C. Carroll (1968 - 1974)

Lawrence M. Noble (1971 - 1976)

S.B. Wilson (1982 - 1990)

J.E. Barnett (1984 - 1990)

Radley H. Daly (1986 - 1991)

Martha K. Matzke (1991 - 1993)

Martha C. Highsmith (1996 - 1999)

Deborah G. Thomas (1999 - 2004)

Donald L. Filer (2000 - 2012)

Patricia D. Zandy (2005 - 2010)

Margaret R. McDonnell (2011 - 2016)

Casey Nagy (2010- 2 012)

Elizabeth Strawn (2010 - 2011)

Carolyn Claflin (2011 - 2012)