There is nothing negative about deleting one of your guides. Sometimes interest in a topic has simply run its course or your have other responsibilities that need your focus.
Ways to identify whether or not your guide has come to the end of its life cycle:
Saying yes to any of these questions means you should take a closer look at whether or not your guide should stay published or whether it's time for its status to change.
Should you decide to remove your guide from public view you have three choices in how to proceed: unpublish, make private, or delete.
You can change a guide's status to Unpublished or Private within the guide itself. To delete a guide you need to go under Content to Guides and then find your guide in the list and click on the X to delete.